Tubular Mechanism for the Spontaneous Hypercalciuria in Laboratory Rat

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Tubular mechanism for the spontaneous hypercalciuria in laboratory rat.

Recently it has been observed that Ca excretion in laboratory rats does not follow a Gaussian distribution, with approximately 10% of them excreting Ca at a rate of 2 SD above the group mean. This phenomenon has been described as spontaneous hypercalciuria (SH). Our studies were designed to define its mechanism. 48 Wistar rats were subjected to metabolic studies to identify SH, prospectively de...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1982

ISSN: 0021-9738

DOI: 10.1172/jci110680